Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products
نویسندگان
چکیده
منابع مشابه
Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products
A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presented. The method provides access to structurally diverse macrocycles by exploiting the reactivity of transient macrocyclic peptide imines toward inter- and intramolecular nucleophiles. Reactions are performed in aqueous media, in the absence of side chain protecting groups...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2017
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.7b01624